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KMID : 1039420150490060525
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Journal of Pathology and Translational Medicine
2015 Volume.49 No. 6 p.525 ~ p.530
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CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder
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Hong Min-Eui
Ko Young-Hyeh
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Abstract
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Eosinophilic ulcer of the oral mucosa (EUOM) is a very rare, benign, self-limiting ulcerative lesion
of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of CD30+ T-cell
lymphoproliferative disease (LPD) of the oral mucosa. The etiology and pathogenesis of the disease
are unknown. We report two cases in children who were initially diagnosed with EUOM and
CD30+ T-cell LPD, respectively. However, retrospective analysis revealed that a majority of infiltrated
atypical T cells were positive for Epstein-Barr virus (EBV). The present cases suggest that the
pathogenesis and etiology of EUOM or CD30+ T-cell LPD occurring in children are different from
those in adults. EUOM or CD30+ T-cell LPD in children is a manifestation of EBV-positive T-cell LPD,
and should therefore be distinguished from the disease in adults.
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KEYWORD
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Eosinophilic ulcer, CD30 positive, Lymphoproliferative disorders, Oral mucosa, Epstein-Barr virus infections, Lymphoreticular
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